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Case Reports
. 2006 Jul;38(7):749-51.
doi: 10.1038/ng1813. Epub 2006 Jun 4.

Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein

Ramon Y Birnbaum  1 , Alex Zvulunov, Dafna Hallel-Halevy, Emanuella Cagnano, Gal Finer, Rivka Ofir, Dan Geiger, Eldad Silberstein, Yael Feferman, Ohad S Birk
Affiliations
Case Reports

Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein

Ramon Y Birnbaum et al. Nat Genet. 2006 Jul.

Abstract

We describe an Israeli Jewish Moroccan family presenting with autosomal dominant seborrhea-like dermatosis with psoriasiform elements, including enhanced keratinocyte proliferation, parakeratosis, follicular plugging, Pityrosporum ovale overgrowth and dermal CD4 lymphocyte infiltrate. We mapped the disease gene to a 0.5-cM region overlapping the PSORS2 locus (17q25) and identified a frameshift mutation in ZNF750, which encodes a putative C2H2 zinc finger protein. ZNF750 is normally expressed in keratinocytes but not in fibroblasts and is barely detectable in CD4 lymphocytes.

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