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. 2006 Jun;4(6):e203.
doi: 10.1371/journal.pbio.0040203. Epub 2006 Jun 13.

DNA repair: dynamic defenders against cancer and aging

Jill O Fuss  1 , Priscilla K Cooper
Affiliations

DNA repair: dynamic defenders against cancer and aging

Jill O Fuss et al. PLoS Biol. 2006 Jun.

Abstract

This primer provides an introduction to mechanisms involved in DNA repair, specifically nucleotide excision repair, and their relevance to disease.

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Figures

Figure 1
Figure 1. Nucleotide Excision Repair Schematic
When DNA is damaged by sunlight, the damage is recognized differently depending on whether the DNA is transcriptionally active (transcription-coupled repair) or not (global excision repair). After the initial recognition step, the damage is repaired in a similar manner with the final outcome being the restoration of the normal nucleotide sequence. A more detailed description is provided in the text.
Figure 2
Figure 2. TFIIH Is a Multi-Functional Protein Complex
TFIIH participates in normal transcription, NER, and TCR and has multiple functions in each of these processes. A medium-resolution electron microscopy structure of the human TFIIH complex [ 36] shows that TFIIH forms a ring-like structure with a protrusion that contains the CAK kinase complex.
See this image and copyright information in PMC

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