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Comment
. 2006 Jun 13;103(24):8913-4.
doi: 10.1073/pnas.0603508103. Epub 2006 Jun 5.

Inducing endogenous antimicrobial peptides to battle infections

Michael Zasloff  1
Affiliations
Comment

Inducing endogenous antimicrobial peptides to battle infections

Michael Zasloff. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

Conflict of interest statement: No conflicts declared.

Figures

Fig. 1.
Fig. 1.
Inducing rectal epithelial antimicrobial genes to battle Shigella. The rectal colon is depicted in the setting of a Shigella infection (A) and after the resolution of the infection by oral administration of sodium butyrate (B). (A) Shigella infection. Microbes approach the epithelium and suppress expression of LL-37. In the absence of LL-37, microbes can invade the epithelial barrier; their presence stimulates a secondary invasion of neutrophils into the submucosa to defend the colon. (B) Treatment with sodium butyrate. Butyrate enters the small intestine and interacts with the epithelium either by direct interaction within the lumen or after absorption into the bloodstream [the route is not described by Raqib et al. (2)]. Butyrate induces LL-37 transcription, peptide synthesis, and secretion. Shigella is rapidly killed by the peptide. Neutrophil migration ceases, and normal cellularity of the mucosa is restored.
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Comment on

References

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