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Comment
. 2006 Jun 6;174(12):1729.
doi: 10.1503/cmaj.060502.

Understanding clopidogrel efficacy in the presence of cytochrome P450 polymorphism

Affiliations
Comment

Understanding clopidogrel efficacy in the presence of cytochrome P450 polymorphism

Jacques Turgeon et al. CMAJ. .
No abstract available

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References

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    1. Savi P, Herbert JM, Pflieger AM, et al. Importance of hepatic metabolism in the antiaggregating activity of the thienopyridine clopidogrel. Biochem Pharmacol 1992;44:527-32. - PubMed
    1. Herbert JM, Savi P, Maffrand JP. Biochemical and pharmacological properties of clopidogrel: a new ADP receptor antagonist. Eur Heart J 1999;(Suppl 1):A31-40.
    1. Clarke TA, Waskell LA. The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin. Drug Metab Dispos 2003;31:53-9. - PubMed
    1. Lau WC, Waskell LA, Watkins PB, et al. Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug–drug interaction. Circulation 2003;107:32-7. - PubMed

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