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. 2006 Jun 14;128(23):7442-3.
doi: 10.1021/ja062091r.

Organocatalytic enantioselective synthesis of alpha-hydroxy phosphonates

Sampak Samanta  1 , Cong-Gui Zhao
Affiliations

Organocatalytic enantioselective synthesis of alpha-hydroxy phosphonates

Sampak Samanta et al. J Am Chem Soc. .

Abstract

Tertiary alpha-hydroxy phosphonates have been synthesized in good yields and high enantiomeric purity (up to 99% ee) through a novel l-proline-catalyzed cross aldol reaction of alpha-keto phosphonates and ketones.

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Figures

Figure 1
Figure 1
Catalysts Screened for the Cross Aldol Reaction
Scheme 1
Scheme 1
See this image and copyright information in PMC

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