doi: 10.1016/0014-2999(77)90163-7.
Vascular beta-adrenoceptor stimulating properties of phenylephrine
- PMID: 16757
- DOI: 10.1016/0014-2999(77)90163-7
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Vascular beta-adrenoceptor stimulating properties of phenylephrine
Eur J Pharmacol.
.
Abstract
In pithed rats pretreated with propranolol changes occurred in the slopes of dose--pressor response curves to i.v. phenylephrine and noradrenaline but not to LD 3098, a pure alpha-adrenoceptor stimulant. In dogs, cats, and spontaneously hypertensive rats pretreated with an alpha-adrenoceptor blocker, i.v. phenylephrine induced vasodilatory responses which were antagonised by propranolol. These results indicate that phenylephrine, in addition to its known beta1-agonistic properties, stimulates the vascular beta2-adrenoceptors.
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