Puberty and prenatal growth
- PMID: 16757105
- DOI: 10.1016/j.mce.2006.04.010
Puberty and prenatal growth
Abstract
There is increasing evidence for a link between puberty and prenatal growth. Here we highlight a selection of pubertal characteristics in children who were born small-for-gestational-age (SGA). Boys born SGA are at risk for high FSH and low inhibin B levels, and a small testicular volume in adolescence. In girls born SGA, the age at pubertal onset and the age at menarche are advanced by about 5-10 months; prenatal growth restraint may be associated with higher FSH levels and with small internal genitalia in adolescence. The ovulation rate was found to be low in SGA adolescents, and an insulin-sensitizing therapy was capable of raising this low ovulation rate. Menarche is definitely advanced in SGA girls with precocious pubarche. Current evidence suggests that insulin resistance is a key mechanism linking a post-SGA state to early menarche; hence, insulin sensitization may become a valid approach to prevent early menarche and early growth arrest in SGA girls.
Similar articles
-
Puberty after prenatal growth restraint.Horm Res. 2006;65 Suppl 3:112-5. doi: 10.1159/000091515. Epub 2006 Apr 10. Horm Res. 2006. PMID: 16612123 Review.
-
Early puberty-menarche after precocious pubarche: relation to prenatal growth.Pediatrics. 2006 Jan;117(1):117-21. doi: 10.1542/peds.2005-0664. Pediatrics. 2006. PMID: 16396868
-
Growth and growth hormone treatment in short stature children born small for gestational age.Pediatr Endocrinol Rev. 2009 Feb;6 Suppl 3:350-7. Pediatr Endocrinol Rev. 2009. PMID: 19404234 Review.
-
Impact of being born small for gestational age on onset and progression of puberty.Best Pract Res Clin Endocrinol Metab. 2008 Jun;22(3):463-76. doi: 10.1016/j.beem.2008.02.003. Best Pract Res Clin Endocrinol Metab. 2008. PMID: 18538286 Review.
-
Overnight levels of luteinizing hormone, follicle-stimulating hormone and growth hormone before and during gonadotropin-releasing hormone analogue treatment in short boys born small for gestational age.Horm Res. 2009;71(5):260-7. doi: 10.1159/000208799. Epub 2009 Apr 1. Horm Res. 2009. PMID: 19339790 Clinical Trial.
Cited by
-
Inactivation of the Celf1 gene that encodes an RNA-binding protein delays the first wave of spermatogenesis in mice.PLoS One. 2012;7(10):e46337. doi: 10.1371/journal.pone.0046337. Epub 2012 Oct 2. PLoS One. 2012. PMID: 23056285 Free PMC article.
-
Adverse effects of female obesity and interaction with race on reproductive potential.Fertil Steril. 2017 Apr;107(4):868-877. doi: 10.1016/j.fertnstert.2017.02.114. Fertil Steril. 2017. PMID: 28366413 Free PMC article. Review.
-
Maternal undernutrition induces premature reproductive senescence in adult female rat offspring.Fertil Steril. 2015 Jan;103(1):291-8.e2. doi: 10.1016/j.fertnstert.2014.09.026. Epub 2014 Oct 28. Fertil Steril. 2015. PMID: 25439841 Free PMC article.
-
Endocrine-disrupting chemicals: an Endocrine Society scientific statement.Endocr Rev. 2009 Jun;30(4):293-342. doi: 10.1210/er.2009-0002. Endocr Rev. 2009. PMID: 19502515 Free PMC article. Review.
-
Effects on transcriptional regulation and lipid droplet characteristics in the liver of female juvenile pigs after early postnatal feed restriction and refeeding are dependent on birth weight.PLoS One. 2013 Nov 19;8(11):e76705. doi: 10.1371/journal.pone.0076705. eCollection 2013. PLoS One. 2013. PMID: 24260100 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical