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. 2006 Jun;44(6):2237-9.
doi: 10.1128/JCM.00285-06.

Value of the chlorhexidine decontamination method for recovery of nontuberculous mycobacteria from sputum samples of patients with cystic fibrosis

Agnès Ferroni  1 , Hoang Vu-Thien, Philippe Lanotte, Muriel Le Bourgeois, Isabelle Sermet-Gaudelus, Brigitte Fauroux, Sophie Marchand, Françoise Varaigne, Patrick Berche, Jean-Louis Gaillard, Catherine Offredo
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Value of the chlorhexidine decontamination method for recovery of nontuberculous mycobacteria from sputum samples of patients with cystic fibrosis

Agnès Ferroni et al. J Clin Microbiol. 2006 Jun.

Abstract

The chlorhexidine method was compared to the N-acetyl-l-cysteine-NaOH-oxalic acid decontamination method currently recommended for the recovery of nontuberculous mycobacteria (NTM) from patients with cystic fibrosis. Sputum samples (n = 827) treated with chlorhexidine yielded twice as many NTM-positive cultures as those treated by the reference method (54 [6.50%] versus 27 [3.25%]; P < 0.0001) despite a higher contamination rate (20% versus 14.2%; P = 0.0017).

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