Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Nov;140(5):554-7.
doi: 10.1007/s10517-006-0022-6.

Induction of differentiation in leukemic cell strains with myelopeptide-4

E A Kirilina  1 , N I Suvorov, S S Popova, S V Khaidukov, E M Rapoport, L A Fonina, A A Mikhailova
Affiliations

Induction of differentiation in leukemic cell strains with myelopeptide-4

E A Kirilina et al. Bull Exp Biol Med. 2005 Nov.

Abstract

We studied the capacity of myelopeptide-4 (regulatory peptide of the bone marrow origin) to induce terminal differentiation of HL-60 and K-562 leukemic cells. Myelopeptide-4 increased the expression of CD14 and CD38 differentiation antigens on the surface of HL-60 cells and of CD44 antigen on K-562 cells, induced the appearance of mature monocyte/macrophages in HL-60 culture and hemoglobin-producing cells in K-562 cell culture, and stimulated phagocytic activity of THP-1 leukemic cells. Myelopeptide-4 is an endogenous factor of cell differentiation, a prospective agent for antileukemic therapy.

PubMed Disclaimer

Substances