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. 2006 Mar 24:1:6.
doi: 10.1186/1749-7922-1-6.

Plasma total anti-oxidant capacity correlates inversely with the extent of acute appendicitis: a case control study

Mehmet Ozdogan  1 , Ali Onder Devay, Ahmet Gurer, Eren Ersoy, Seda Duygulu Devay, Hakan Kulacoglu, Haldun Gundogdu
Affiliations

Plasma total anti-oxidant capacity correlates inversely with the extent of acute appendicitis: a case control study

Mehmet Ozdogan et al. World J Emerg Surg. .

Abstract

Background: The role of free oxygen radicals in inflammatory conditions is well known. Free radicals cause lipid peroxidation of cellular membranes resulting in cell death. The purpose of this study was to investigate the levels of total anti-oxidant status (TAS), as a marker of anti-oxidant defense system and malondialdehyde (MDA), as a marker of oxidative stress, in the plasma of patients with acute appendicitis.

Methods: Fifty-one adult patients with a median age of 31 years who underwent operations with a preoperative diagnosis of acute appendicitis were included in this prospective study. Blood samples for C-reactive protein (CRP), MDA and TAS were collected preoperatively. Groups were compared by using the Mann-Whitney U test.

Results: There were 27 patients with acute phlagmenous appendicitis and 19 patients with advanced appendicitis (10 gangrenous and 9 perforated appendicitis), while 5 negative explorations were documented. No significant differences in WBC counts and MDA levels between groups were encountered. Plasma CRP was significantly higher in patients with perforated appendicitis, but not in the other groups. In advanced appendicitis group, TAS level was significantly lower than the other groups. On the other hand, plasma TAS level in acute phlagmenous appendicitis group was significantly higher.

Conclusion: A decrease in plasma total anti-oxidant capacity might be a predictor of the progression of inflammation to the perforation in acute appendicitis.

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Figures

Figure 1
Figure 1
Mean values of serum CRP according to the different histological diagnosis.
Figure 2
Figure 2
Mean values of serum TAS according to the different histological diagnosis (Advanced: PA and GA groups).
See this image and copyright information in PMC

References

    1. Chang AR. An analysis of the pathology of 3003 appendices. Aust N Z J Surg. 1981;51:169–178. - PubMed
    1. Rodriguez-Sanjuan JC, Martin-Parra JI, Seco I, Garcia-Castrillo L, Naranjo A. C-reactive protein and leukocyte count in the diagnosis of acute appendicitis in children. Dis Colon Rectum. 1999;42:1325–1329. doi: 10.1007/BF02234223. - DOI - PubMed
    1. Hallan S, Asberg A, Edna TH. Additional value of biochemical tests in suspected acute appendicitis. Eur J Surg. 1997;163:533–538. - PubMed
    1. Andersson RE, Hugander AP, Ghazi SH, Ravn H, Offenbartl SK, Nystrom PO, Olaison GP. Diagnostic value of disease history, clinical presentation, and inflammatory parameters of appendicitis. World J Surg. 1999;23:133–140. doi: 10.1007/PL00013174. - DOI - PubMed
    1. Korner H, Sondenaa K, Soreide JA. Perforated and non-perforated acute appendicitis – one disease or two entities? Eur J Surg. 2001;167:525–530. doi: 10.1080/110241501316914902. - DOI - PubMed