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. 2006 Jul;14(7):299-303.
doi: 10.1016/j.tim.2006.05.007. Epub 2006 Jun 8.

Is there an ideal animal model for SARS?

Kanta Subbarao  1 , Anjeanette Roberts
Affiliations

Is there an ideal animal model for SARS?

Kanta Subbarao et al. Trends Microbiol. 2006 Jul.

Abstract

The outbreak of severe acute respiratory syndrome (SARS) in 2003 was controlled by public health measures at a time when specific interventions such as antiviral drugs, vaccines and immunotherapy were not available. Since then, several animal models have been developed for the study of SARS and, although no model replicates the human disease in all aspects, the use of animal models for SARS has led to the establishment of several important principles for vaccine and immunotherapy. Consistency and reproducibility of findings in a given model must be demonstrated to establish the superiority of one model over others. Here, we suggest aspects of an ideal animal model for studies of SARS pathogenesis and vaccine development and present our assessment of the strengths and limitations of the current animal models for SARS.

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References

    1. Drosten C. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N. Engl. J. Med. 2003;348:1967–1976. - PubMed
    1. Ksiazek T.G. A novel coronavirus associated with severe acute respiratory syndrome. N. Engl. J. Med. 2003;348:1953–1966. - PubMed
    1. Peiris J.S. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 2003;361:1319–1325. - PMC - PubMed
    1. Poutanen S.M. Identification of severe acute respiratory syndrome in Canada. N. Engl. J. Med. 2003;348:1995–2005. - PubMed
    1. Guan Y. Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China. Science. 2003;302:276–278. - PubMed

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