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. 2006 Sep 15;14(18):6434-43.
doi: 10.1016/j.bmc.2006.05.036. Epub 2006 Jun 8.

Synthesis of novel 5-substituted indirubins as protein kinases inhibitors

Anne Beauchard  1 , Yoan Ferandin, Stéphane Frère, Olivier Lozach, Mélina Blairvacq, Laurent Meijer, Valérie Thiéry, Thierry Besson
Affiliations

Synthesis of novel 5-substituted indirubins as protein kinases inhibitors

Anne Beauchard et al. Bioorg Med Chem. .

Abstract

In an effort to identify new pharmacological inhibitors of disease-relevant protein kinases with increased potency and selectivity, we synthesized and evaluated new 5-substituted indirubins. The effects of 34 indirubin derivatives on CDK1/cyclin B, CDK5/p25, and GSK-3, as well as on SH-SY5Y human neuroblastoma cell survival, were investigated.

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