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. 2006 Jun;5(12):1281-5.
doi: 10.4161/cc.5.12.2806. Epub 2006 Jun 15.

Controlling stem cell proliferation: CKIs at work

Sophia W M Bruggeman  1 , Maarten van Lohuizen
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Controlling stem cell proliferation: CKIs at work

Sophia W M Bruggeman et al. Cell Cycle. 2006 Jun.

Abstract

The cyclin-dependent kinase inhibitors or CKIs are well recognized as intrinsic regulators of the cell cycle. Here, we discuss recent data implicating their activity in restraining adult stem cell self-renewal, and the role that proteins regulating CKI expression play in this process.

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