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Comment
. 2006 Jun;69(12):2116-8.
doi: 10.1038/sj.ki.5000435.

Cellular mechanisms of WNK4-mediated regulation of ion transport proteins in the distal tubule

J-B Peng  1 , P D Bell
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Free article
Comment

Cellular mechanisms of WNK4-mediated regulation of ion transport proteins in the distal tubule

J-B Peng et al. Kidney Int. 2006 Jun.
Free article

Abstract

Gene mutations in WNK4 kinase cause a genetic form of hypertension by affecting multiple ion transport pathways through different mechanisms. Cai et al. report that the inhibitory effect of WNK4 on the thiazide-sensitive sodium-chloride cotransporter occurs through the lysosomal degradation pathway in mammalian cells.

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