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Review
. 2006 Jun;6(6):905-9.
doi: 10.1586/14737140.6.6.905.

Immunomodulatory and antitumor effects of interleukin-21 in patients with renal cell carcinoma

Brendan D Curti  1
Affiliations
Review

Immunomodulatory and antitumor effects of interleukin-21 in patients with renal cell carcinoma

Brendan D Curti. Expert Rev Anticancer Ther. 2006 Jun.

Abstract

Interleukin (IL)-21 is a class I cytokine with sequence homology to the IL-2 cytokine superfamily. IL-21 signals through a heterodimer of a unique IL-21 receptor and the common gamma-chain cytokine receptor. Preclinical murine models suggested strong antitumor activity of IL-21 in renal cell carcinoma, melanoma and other tumor models. IL-21 antitumor activity was superior to IL-2 in these tumor models. A Phase I clinical trial of IL-21 in humans with metastatic renal cell carcinoma or melanoma began in May 2004. Clinical regressions were observed in renal cell carcinoma. Preliminary immunological and clinical findings of patients receiving IL-21 will be reviewed.

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