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Review
. 1991 Apr;12(4):102-5.
doi: 10.1016/0167-5699(91)90092-8.

Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis

J C Ameisen  1 , A Capron
Affiliations
Review

Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis

J C Ameisen et al. Immunol Today. 1991 Apr.

Abstract

Normal immature thymocytes respond to activation by undergoing programmed cell death (apoptosis), a physiological deletion mechanism involved in the selection of the T-cell repertoire. In this article, Jean Claude Ameisen and André Capron suggest that inappropriate induction of a form of programmed T-cell death could account for both qualitative and quantitative helper T-cell defects of HIV-infected patients. A model of AIDS pathogenesis is presented that may explain several features of HIV infection, including evolution of the disease and the development of defects in nonimmunological organs.

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Comment in

  • AIDS and programmed cell death.
    Sheppard HW, Ascher MS. Sheppard HW, et al. Immunol Today. 1991 Nov;12(11):423. doi: 10.1016/0167-5699(91)90149-N. Immunol Today. 1991. PMID: 1786077 No abstract available.

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