Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 May;26(5):623-5, 637.

[Linkage analysis of keloid susceptibility loci on chromosome 7p11 in a Chinese pedigree]

[Article in Chinese]
Yang Chen  1 , Jian-hua Gao, Xiao-jun Liu, Xin Yan, Mei Song
Affiliations
  • PMID: 16762867

[Linkage analysis of keloid susceptibility loci on chromosome 7p11 in a Chinese pedigree]

[Article in Chinese]
Yang Chen et al. Nan Fang Yi Ke Da Xue Xue Bao. 2006 May.

Abstract

Objective: To investigate whether the keloid susceptibility loci occur on chromosome 7p11 in a Chinese pedigree.

Methods: Peripheral venous blood samples from 32 members significant for hereditary investigation from a large Chinese keloid pedigree (with 5 affected generations) were collected for extracting genomic DNA. Four microsatellites on chromosome 7p11 with known maximal two-point LOD scores were selected as the genetic markers according to the method described in a recent report of the similar study. These markers were subsequently amplified by PCR, and all the PCR products were genotyped and linkage analyses were conducted.

Results: With the theta value of 0-0.1, the two-point LOD scores for these markers were all less than -2, which excluded the linkages of these markers to chromosome 7p11.

Conclusion: This study provides the first genetic evidence that keloid susceptibility loci in Chinese pedigree do not locate on chromosome 7p11, suggesting the heterogeneity of familial keloid susceptibility loci.

PubMed Disclaimer

Publication types