Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Jul 1;140(13):1359-65.
doi: 10.1002/ajmg.a.31304.

The expanding panorama of split hand foot malformation

Donald Basel  1 , Michael W Kilpatrick, Petros Tsipouras
Affiliations
Review

The expanding panorama of split hand foot malformation

Donald Basel et al. Am J Med Genet A. .

Abstract

The split hand/foot malformation is a developmental defect of the extremities resulting from errors in the initiation and maintenance of the apical ectodermal ridge. The phenotype is genetically heterogeneous, and it can be identified either as an isolated phenotypic manifestation or as a constituent component of a malformation syndrome. This overview describes the clinical phenotype, related animal models, and the evolving genetic heterogeneity of the malformation.

PubMed Disclaimer

Comment in

MeSH terms

LinkOut - more resources