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Case Reports
. 2006 Jun;141(6):1162-3.
doi: 10.1016/j.ajo.2006.01.067.

Detection of Chlamydia pneumoniae in a bilateral orbital mucosa-associated lymphoid tissue lymphoma

Defen Shen  1 , Hunter K L Yuen, Dan A Galita, Nongnart R Chan, Chi-Chao Chan
Affiliations
Case Reports

Detection of Chlamydia pneumoniae in a bilateral orbital mucosa-associated lymphoid tissue lymphoma

Defen Shen et al. Am J Ophthalmol. 2006 Jun.

Abstract

Purpose: To detect Chlamydia pneumoniae (C. pneumoniae) gene in a patient with bilateral orbital musoca-associated lymphoid tissue (MALT) lymphoma.

Design: Interventional case report.

Methods: A 47-year-old Chinese man with recurrent bilateral orbital masses underwent surgical biopsy. Ophthalmologic and radiographic examinations, routine histology, immunohistochemistry, and molecular analysis for immunoglobulin heavy chain (IgH), bcl-2/IgH gene translocation, and Chlamydia genes were performed.

Results: Pathology revealed orbital MALT lymphoma with B-cell monoclonality. In addition to IgH gene rearrangement, C. pneumoniae DNA was detected in the lymphoma.

Conclusions: The finding of C. pneumoniae molecular signatures in this case suggests a possible association of Chlamydia and orbital MALT lymphoma. The infection may contribute to the development of the lymphoma.

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Figures

FIGURE 1
FIGURE 1
Orbital CT scan showing bilateral tumor invasion. CT scan demonstrates bilateral infiltrative orbital masses with extraconal and intraconal orbital involvements that molded over the globes and bones without bone destruction.
FIGURE 2
FIGURE 2
Microphotograph showing typical MALT lymphoma. There is a monotonous population of small atypical lymphocytes, some with plasmacytic differentiation. Occasional Russell and Dutcher bodies are present (purple red color). Inset. Most cells are positive (black color) for CD20. (hematoxylin and eosin and avidin-biotin immunoperoxidase (inset); original magnification, ×100).
FIGURE 3
FIGURE 3
Polymerase chain reaction (PCR) products showing C. pneumoniae DNA in orbital MALT lymphoma. IgH gene rearrangement at the CDR3 region and bcl-2/IgH gene translocation (tl4;18), as well as C. pneumoniae gene are detected in the microdissected MALT lymphoma cells (lane 1, patient; lane 2, negative control; lane 3, positive control).
See this image and copyright information in PMC

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