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Clinical Trial
. 1991 Mar;10(1):43-8.
doi: 10.1007/BF02208032.

Sulphasalazine in ankylosing spondylitis. A radiological, clinical and laboratory assessment

H G Taylor  1 , E J Beswick, P T Dawes
Affiliations
Clinical Trial

Sulphasalazine in ankylosing spondylitis. A radiological, clinical and laboratory assessment

H G Taylor et al. Clin Rheumatol. 1991 Mar.

Abstract

In a 12-month double-blind placebo-controlled trial, the effect of sulphasalazine was studied in 40 patients with ankylosing spondylitis. The treatment group showed significant improvement in pain, stiffness, sleep disturbance (p less than 0.05), finger/floor distance, erythrocyte sedimentation rate, C-reactive protein, orosomucoid and IgA levels (p less than 0.01). There was improvement in sleep disturbance (p less than 0.05), finger/floor distance and erythrocyte sedimentation rate (p less than 0.01) in the placebo group. Sulphasalazine did not retard radiological progression as measured either by plain X-ray or computerised tomographic scans. Multiple analysis of variance did not show a significant difference in disease activity indicators between the 2 groups.

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References

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