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. 1975 Feb;213(2):186-9.

Flavoxate, a potent phosphodiesterase inhibitor

M Conti, I Setnikar
  • PMID: 167667

Flavoxate, a potent phosphodiesterase inhibitor

M Conti et al. Arch Int Pharmacodyn Ther. 1975 Feb.

Abstract

The c-AMP phosphodiesterase inhibiting properties of flavoxate and of its main metabolite i.e. 3-methylflavone-8-carboxylic acid (MFCA), were assayed in vitro and compared to those of theophylline. Flavoxate and MFCA are competitive phosphodiesterase inhibitors, and are 21 and respectively 5 times more potent than theophylline. The smooth muscle relaxing activity of flavoxate possibly relies on this enzymatic mechanism.

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