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. 2006 Jul;24(7):817-9.
doi: 10.1038/nbt1215. Epub 2006 Jun 11.

A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virus

Magdalini Moutaftsi  1 , Bjoern Peters, Valerie Pasquetto, David C Tscharke, John Sidney, Huynh-Hoa Bui, Howard Grey, Alessandro Sette
Affiliations

A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virus

Magdalini Moutaftsi et al. Nat Biotechnol. 2006 Jul.

Abstract

The value of predictive algorithms for identifying CD8+ T (T(CD8+))-cell epitopes has not been adequately tested experimentally. Here we demonstrate that conventional bioinformatic methods predict the vast majority of T(CD8+)-cell epitopes derived from vaccinia virus WR strain (VACV-WR) in the H-2(b) mouse model. This approach reveals the breadth of T-cell responses to vaccinia, a widely studied murine viral infection model, and may provide a tool for developing comprehensive antigenic maps of any complex pathogen.

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Comment in

  • Putting immunoinformatics to the test.
    Moise L, De Groot AS. Moise L, et al. Nat Biotechnol. 2006 Jul;24(7):791-2. doi: 10.1038/nbt0706-791. Nat Biotechnol. 2006. PMID: 16841062 No abstract available.

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