Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975;48(1):1-8.
doi: 10.1007/BF01320560.

Virulence of temperature-sensitive mutants of foot-and-mouth disease virus

J S MacKenzie

Virulence of temperature-sensitive mutants of foot-and-mouth disease virus

J S MacKenzie. Arch Virol. 1975.

Abstract

A number of temperature-sensitive mutants isolated from two strains of foot-and-mouth disease virus were examined for their virulence in suckling mice. The majority of the mutants were found to be less virulent than the parent virus strains, ranging from slight to total attenuation, but two mutants retained parental levels of virulence. There was no correlation between mutant cut-off temperatures and virulence, or the revertant content of mutant preparations and virulence. It was not always possible to regain parental levels of virulence by isolating phenotypic revertants or wild-type recombinants from genetic crosses, but recombinants were significantly more virulent than either of the two input viruses in a genetic cross.

PubMed Disclaimer

References

    1. Br Med J. 1969 Sep 27;3(5673):757-8 - PubMed
    1. J Gen Virol. 1968 May;2(3):319-29 - PubMed
    1. J Immunol. 1969 Mar;102(3):728-32 - PubMed
    1. J Hyg (Lond). 1972 Jun;70(2):229-34 - PubMed
    1. J Infect Dis. 1971 Feb;123(2):145-57 - PubMed