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. 2006 Sep 15;172(1):173-8.
doi: 10.1016/j.bbr.2006.05.012. Epub 2006 Jun 12.

d-Cycloserine facilitates extinction of a cocaine-induced conditioned place preference

Fanny Botreau  1 , Giovanna Paolone, Jane Stewart
Affiliations

d-Cycloserine facilitates extinction of a cocaine-induced conditioned place preference

Fanny Botreau et al. Behav Brain Res. .

Abstract

d-Cycloserine, a partial NMDA agonist, significantly accelerated extinction of a cocaine-induced conditioned place preference (CPP) when rats were given systemic injections immediately, but not 4h, after each extinction trial. Infusions directly into the basolateral amygdala had a similar effect. The facilitative effect of d-cycloserine on the extinction of appetitive conditioning is consistent with the idea of the formation of new learned associations during extinction.

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