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. 1975;48(2):157-68.
doi: 10.1007/BF01318148.

Identification of strains of herpes simplex virus by comparison of the density of their DNA using the preparative ultracentrifuge

I W Halliburton, E A Hill, G J Russell

Identification of strains of herpes simplex virus by comparison of the density of their DNA using the preparative ultracentrifuge

I W Halliburton et al. Arch Virol. 1975.

Abstract

The buoyant densities of the DNA of herpes simplex virus type 1, type 2 and Pseudorabies virus, as determined in the analytical ultracentrifuge, are 1.725, 1.727 and 1.731 correlating with G+C contents of 67, 69 and 73 per cent respectively. The density differences for the DNA's of type 1 and type 2 herpes simplex viruses have been confirmed in experiments with isotopically labelled DNA from four type 1 and six type 2 strains by preparative CsCl gradient ultracentrifugation. The DNA of all the type 2 strains was denser than that of any of the type 1 strains examined. Despite these differences in DNA base composition of type 1 and type 2 strains, nearest neighbour analysis of their DNA's disclosed no obvious differences in doublet pattern or general design.

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