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Case Reports
. 2006 Jun;148(6):831-4.
doi: 10.1016/j.jpeds.2006.01.035.

Severe liver injury after initiating therapy with atomoxetine in two children

Joel R Lim  1 , Philip R Faught, Naga P Chalasani, Jean P Molleston
Affiliations
Case Reports

Severe liver injury after initiating therapy with atomoxetine in two children

Joel R Lim et al. J Pediatr. 2006 Jun.

Abstract

Two children presented with acute hepatitis after starting therapy with atomoxetine (Strattera). In one child, no competing diagnosis could be identified, and liver injury resolved completely on withdrawal of the medication. In the second child, the evaluation was suggestive of type 1 autoimmune hepatitis; she subsequently improved with removal of atomoxetine and concomitant immunosuppressive therapy. Atomoxetine may cause clinically significant hepatotoxicity either by metabolic idiosyncrasy or by inducing autoimmune hepatitis.

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