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Review
. 2006 Jun;19(6):446-57.
doi: 10.1111/j.1432-2277.2006.00321.x.

Interleukin-2 receptor antagonist induction in modern immunosuppression regimens for renal transplant recipients

Flavio Vincenti  1 , Amado de Andrés, Thomas Becker, Gabriel Choukroun, Edward Cole, José M González-Posada, Mysore A Kumar, Richard Moore, Silvio Nadalin, Björn Nashan, Lionel Rostaing, Kazuhide Saito, Norio Yoshimura
Affiliations
Free article
Review

Interleukin-2 receptor antagonist induction in modern immunosuppression regimens for renal transplant recipients

Flavio Vincenti et al. Transpl Int. 2006 Jun.
Free article

Abstract

Addition of interleukin-2 receptor antagonist (IL-2RA) induction to calcineurin inhibitor (CNI)-based regimens reduces biopsy-proven acute rejection by 30-40%. IL-2RA induction facilitates early withdrawal of steroids, and supports the safe use of reduced-exposure CNI or delayed CNI introduction. IL-2RAs and rabbit antithymocyte globulin (Thymoglobulin) show comparable efficacy in patients at standard or low immunologic risk, but the adverse event profiles of lymphocyte-depleting agents are less favorable. IL-2RAs, uniquely, provide effective immunosuppression with similar tolerability to placebo.

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