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Review
. 2006 Jun;20(2):193-205.
doi: 10.1016/j.beem.2006.02.005.

Diagnosis, epidemiology, and genetics of the polycystic ovary syndrome

Affiliations
Review

Diagnosis, epidemiology, and genetics of the polycystic ovary syndrome

Mark O Goodarzi et al. Best Pract Res Clin Endocrinol Metab. 2006 Jun.

Abstract

Polycystic ovary syndrome (PCOS) is a heterogeneous disorder, and its definition remains fluid and controversial. PCOS is characterized by clinical and/or biochemical hyperandrogenism, and is frequently accompanied by ovulatory dysfunction and polycystic ovaries. PCOS is a diagnosis of exclusion, with other androgen excess and related disorders to be excluded. The prevalence of PCOS is 6.5-8.0% of unselected women of reproductive age, using the NIH 1990 criteria. Genetically, PCOS is a common, complex disorder. Despite repeated attempts to identify the putative gene or genes responsible for this disorder, the PCOS gene(s) remain elusive.

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