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Comment
. 2006 Jul;79(1):180-3; author reply 183-4.
doi: 10.1086/505032.

Single-nucleotide polymorphism rs498055 on chromosome 10q24 is not associated with Alzheimer disease in two independent family samples

Lars Bertram, Monica Hsiao, Christoph Lange, Deborah Blacker, Rudolph E Tanzi
Comment

Single-nucleotide polymorphism rs498055 on chromosome 10q24 is not associated with Alzheimer disease in two independent family samples

Lars Bertram et al. Am J Hum Genet. 2006 Jul.
No abstract available

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Figures

Figure 1.
Figure 1.
Power to detect a range of effect sizes in the family samples analyzed. Power estimates were done with PBAT (v3.1). Estimates are based on approximation and are calculated for an additive disease model based on parameters published by Grupe et al. (i.e., disease-allele frequency of 0.47 and OR 1.2–1.6), with the exception of disease prevalence, which was set to 10%. Although the precise prevalence of AD is unknown and difficult to estimate, power does not change appreciably when prevalence is varied from 5% to 15% (data not shown). ORs are for heterozygous carriers of the disease allele versus homozygous noncarriers. Families were modeled after the observed pedigree structure for each sample, with both parents set as “missing.” Note that PBAT can currently handle a maximum offspring number of only four; however, 68 (16%) of NIMH pedigrees actually have more than four genotyped and phenotyped offspring, so that the power for “NIMH” and “NIMH+CAG” is likely to be underestimated (see the PBAT Web site for more details).
See this image and copyright information in PMC

Comment on

  • A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A. Grupe A, et al. Am J Hum Genet. 2006 Jan;78(1):78-88. doi: 10.1086/498851. Epub 2005 Nov 15. Am J Hum Genet. 2006. PMID: 16385451 Free PMC article.

References

Web Resources

    1. AlzGene, http://www.alzgene.org/ (Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi R. The AlzGene Database–Published AD Candidate Genes; Alzheimer Research Forum; last accessed 3/1/06)
    1. FBAT, http://www.biostat.harvard.edu/~fbat/fbat.htm
    1. Online Mendelian Inheritance in Man (OMIM), http://www.ncbi.nlm.nih.gov/Omim/ (for RPS3A, AD, APOE, and AD6)
    1. PBAT, http://www.biostat.harvard.edu/~clange/default.htm

References

    1. Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JSK, et al (2006) A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. Am J Hum Genet 78:78–88 - PMC - PubMed
    1. Bertram L, Hiltunen M, Parkinson M, Ingelsson M, Lange C, Ramasamy K, Mullin K, Menon R, Sampson AJ, Hsiao MY, Elliott KJ, Velicelebi G, Moscarillo T, Hyman BT, Wagner SL, Becker KD, Blacker D, Tanzi RE (2005) Family-based association between Alzheimer’s disease and variants in UBQLN1. N Engl J Med 352:884–89410.1056/NEJMoa042765 - DOI - PubMed
    1. Lange C, DeMeo DL, Laird NM (2002) Power and design considerations for a general class of family-based association tests: quantitative traits. Am J Hum Genet 71:1330–1341 - PMC - PubMed
    1. Jiang H, Harrington D, Raby BA, Bertram L, Blacker D, Weiss ST, Lange C (2006) Family-based association test for time-to-onset data with time-dependent differences between the hazard functions. Genet Epidemiol 30:124–13210.1002/gepi.20132 - DOI - PubMed
    1. Bertram L, Blacker D, Mullin K, Keeney D, Jones J, Basu S, Yhu S, McInnis MG, Go RC, Vekrellis K, Selkoe DJ, Saunders AJ, Tanzi RE (2000) Evidence for genetic linkage of Alzheimer’s disease to chromosome 10q. Science 290:2302–230310.1126/science.290.5500.2302 - DOI - PubMed