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. 1976 May-Jun;39(3):331-2.

[Sulfaphenazole binding by p-450 cytochrome of liver microsomes of rats and its effect of cytochrome-p-450-reductase]

[Article in Russian]
D Miuller, G Liubbe, K Khoang-Tikh, V Klinger
  • PMID: 16775

[Sulfaphenazole binding by p-450 cytochrome of liver microsomes of rats and its effect of cytochrome-p-450-reductase]

[Article in Russian]
D Miuller et al. Farmakol Toksikol. 1976 May-Jun.

Abstract

Tests set up "in vitro" on the rats' liver microsomes showed that sulfaphenazol, which in an inhibitor of the mixed type N-and O-demethylation, is bound as a substrate of the II type (aniline type). It attenuates spectral changes caused by aniline and vice versa. Sulfaphenazol inhibits the activity of the ADPH cytochrome-P-450-reductase.

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