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Randomized Controlled Trial
. 2006 Dec;92(12):1764-7.
doi: 10.1136/hrt.2005.085431. Epub 2006 Jun 14.

Efficacy of emergent transcatheter transplantation of stem cells for treatment of acute myocardial infarction (TCT-STAMI)

J Ge  1 , Y Li, J Qian, J Shi, Q Wang, Y Niu, B Fan, X Liu, S Zhang, A Sun, Y Zou
Affiliations
Randomized Controlled Trial

Efficacy of emergent transcatheter transplantation of stem cells for treatment of acute myocardial infarction (TCT-STAMI)

J Ge et al. Heart. 2006 Dec.

Abstract

Objective: To study whether emergent intracoronary autologous bone marrow cell transplantation (BMT) is applicable for the treatment of acute myocardial infarction (AMI).

Methods: 20 patients admitted within 24 h after the onset of a first AMI were randomly allocated to receive intracoronary autologous BMT (n = 10) or bone marrow supernatant (controls, n = 10) immediately after primary percutaneous coronary intervention. Left ventricular ejection fraction (LVEF), left ventricular end diastolic internal diameter (LVDd) and myocardial perfusion defect scores were examined respectively by echocardiography and single-photon emission computed tomography at one week and six months after AMI.

Results: From one week to six months after AMI, LVEF was enhanced from mean 53.8 (SD 9.2)% to 58.6 (9.9)% (p < 0.05) in the BMT group but was unchanged in the control group (58.2 (7.5)% v 56.3 (3.5)%, p > 0.05); LVDd remained unchanged (52.5 (2.8) v 52.1 (3.2) mm, p > 0.05) in the BMT group but was significantly enlarged in the control group (50.4 (6.0) v 55.2 (7.1) mm, p < 0.05). Additionally, myocardial perfusion defect scores decreased from 21 (11) to 13 (10) (p < 0.01) in the BMT group but were unchanged in the control group (20 (14) v 17 (15), p > 0.05).

Conclusion: Emergent intracoronary transplantation of bone marrow mononuclear cells after AMI is practicable, and it improved cardiac function, prevented myocardial remodelling and increased myocardial perfusion at six months' follow up.

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References

    1. Orlic D, Kajstura J, Chimenti S.et al Bone marrow cells regenerate infarcted myocardium. Nature 2001410701–705. - PubMed
    1. Kocher A A, Schuster M D, Szabolcs M J.et al Neovascularization of ischemic myocardium by human bone‐marrow‐derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 20017430–436. - PubMed
    1. Tomita S, Mickle D A, Weisel R D.et al Improved heart function with myogenesis and angiogenesis after autologous porcine bone marrow stromal cell transplantation. J Thorac Cardiovasc Surg 20021231132–1135. - PubMed
    1. Tang Y L, Zhao Q, Zhang Y C.et al Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium. Regul Pept 20041173–10. - PubMed
    1. Zhang S, Zhang P, Guo J.et al Enhanced cytoprotection and angiogenesis by bone marrow cell transplantation may contribute to improved ischemic myocardial function. Eur J Cardiothorac Surg 200425188–195. - PubMed

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