doi: 10.1016/0166-3542(91)90033-n.
Carbovir: the (-) enantiomer is a potent and selective antiviral agent against human immunodeficiency virus in vitro
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- PMID: 1677557
- DOI: 10.1016/0166-3542(91)90033-n
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Carbovir: the (-) enantiomer is a potent and selective antiviral agent against human immunodeficiency virus in vitro
Antiviral Res.
1991 Feb.
Abstract
In this paper we describe the in vitro antiviral activity of the (-) enantiomer of carbocyclic 2',3'-deoxydidehydroguanosine, (-) carbovir, a nucleoside analogue that has selective and potent anti-HIV activity in a series of lymphocyte culture systems. The cellular cytotoxicity of this compound has also been evaluated in a number of systems and compared to the saturated dideoxynucleoside analogues AZT and ddC.
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