Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Jun 15:6:99.
doi: 10.1186/1471-2334-6-99.

Secular trends of antimicrobial resistance of blood isolates in a newly founded Greek hospital

Matthew E Falagas  1 , Sofia K Kasiakou, Dimitra Nikita, Panayiota Morfou, George Georgoulias, Petros I Rafailidis
Affiliations

Secular trends of antimicrobial resistance of blood isolates in a newly founded Greek hospital

Matthew E Falagas et al. BMC Infect Dis. .

Abstract

Background: Antimicrobial resistance is one of the most challenging issues in modern medicine.

Methods: We evaluated the secular trends of the relative frequency of blood isolates and of the pattern of their in vitro antimicrobial susceptibility in our hospital during the last four and a half years.

Results: Overall, the data regarding the relative frequency of blood isolates in our newly founded hospital do not differ significantly from those of hospitals that are functioning for a much longer period of time. A noteworthy emerging problem is the increasing antimicrobial resistance of Gram-negative bacteria, mainly Acinetobacter baumannii and Klebsiella pneumoniae to various classes of antibiotics. Acinetobacter baumannii isolates showed an increase of resistance to amikacin (p = 0.019), ciprofloxacin (p = 0.001), imipenem (p < 0.001), and piperacillin/tazobactam (p = 0.01) between the first and second period of the study.

Conclusion: An alarming increase of the antimicrobial resistance of Acinetobacter baumannii isolates has been noted during our study.

PubMed Disclaimer

References

    1. Biedenbach DJ, Moet GJ, Jones RN. Occurrence and antimicrobial resistance pattern comparisons among bloodstream infection isolates from the SENTRY antimicrobial surveillance program (1997–2002) Diagnostic Microbiology and Infectious Disease. 2004;50:59–69. doi: 10.1016/j.diagmicrobio.2004.05.003. - DOI - PubMed
    1. Sader HS, Jones RN, Andrade-Baiocchi S, Biedenbach DJ, SENTRY Participants Group (Latin America) Four-year evaluation of frequency of occurrence and antimicrobial susceptibility patterns of bacteria from bloodstream infections in Latin America medical centers. Diagn Microbiol Infect Dis. 2002;44:271–280. - PubMed
    1. Kato-Maeda M, Bautista-Alavez A, Rolon-Montes-de-Oca AL, Ramos-Hinojosa A, Ponce-de-Leon A, Bobadilla-del-Valle M, Ruiz-Palacios G, Sifuentes-Osornio Increasing trend of antimicrobial drug-resistance in organisms causing bacteremia at a tertiary-care hospital: 1995 to 2000. Rev Invest Clin. 2003;55:600–5. - PubMed
    1. National Committee for Clinical Laboratory Standards . Approved standard M7-A6. NCCLS, Wayne, PA; 2003. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, sixth edition: 2003.
    1. National Committee for Clinical Laboratory Standards . Supplemental tables, M100-S13. NCCLS, Wayne, PA; 2003. Performance standards for antimicrobial susceptibility testing : 2003.

Substances