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Comment
. 2006 Jun 16;125(6):1029-31.
doi: 10.1016/j.cell.2006.05.028.

EGF receptor activation: push comes to shove

Stevan R Hubbard  1
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Free article
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EGF receptor activation: push comes to shove

Stevan R Hubbard. Cell. .
Free article

Abstract

A study by Zhang et al. (2006) in this issue of Cell provides compelling evidence that the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) is activated by the formation of an asymmetric dimer, with one kinase domain in the EGF-mediated dimer activating the other through an allosteric mechanism.

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