Review
PI3K and RAC signalling in leukocyte and cancer cell migration
Affiliations
- PMID: 16777617
Item in Clipboard
Review
PI3K and RAC signalling in leukocyte and cancer cell migration
Bull Cancer.
2006 May.
Free article
Abstract
Leukocytes and amoeboid-stage cancer cells migrate in a similar manner. Key signalling molecules regulating leukocyte and cancer cell migration are phosphoinositide 3-kinase (PI3K) and the Rho family of small GTPases. While PI3K activity defines the leading edge of the cell, Rho family GTPases regulate the cytoskeletal remodelling during polarisation and migration. We review here briefly the roles of PI3K, of the Rho-family GTPase Rac, and of the guanine-nucleotide exchange factors that activate Rac, in leukocyte and cancer cell migration.
Similar articles
-
Roles of PI3Ks in leukocyte chemotaxis and phagocytosis.Curr Opin Cell Biol. 2002 Apr;14(2):203-13. doi: 10.1016/s0955-0674(02)00311-3. Curr Opin Cell Biol. 2002. PMID: 11891120 Review.
-
P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils.J Cell Sci. 2014 Jun 1;127(Pt 11):2589-600. doi: 10.1242/jcs.153049. Epub 2014 Mar 21. J Cell Sci. 2014. PMID: 24659802
-
Rho and Rac take center stage.Cell. 2004 Jan 23;116(2):167-79. doi: 10.1016/s0092-8674(04)00003-0. Cell. 2004. PMID: 14744429 Review.
-
Big roles for small GTPases in the control of directed cell movement.Biochem J. 2007 Jan 15;401(2):377-90. doi: 10.1042/BJ20061432. Biochem J. 2007. PMID: 17173542 Free PMC article. Review.
-
Roles of Rho-family GTPases in cell polarisation and directional migration.Curr Opin Cell Biol. 2003 Oct;15(5):590-7. doi: 10.1016/s0955-0674(03)00097-8. Curr Opin Cell Biol. 2003. PMID: 14519394 Review.
Cited by
-
RhoB loss induces Rac1-dependent mesenchymal cell invasion in lung cells through PP2A inhibition.Oncogene. 2016 Apr 7;35(14):1760-9. doi: 10.1038/onc.2015.240. Epub 2015 Jul 6. Oncogene. 2016. PMID: 26148238
-
MiR-139-5p: promising biomarker for cancer.Tumour Biol. 2015 Mar;36(3):1355-65. doi: 10.1007/s13277-015-3199-3. Epub 2015 Feb 19. Tumour Biol. 2015. PMID: 25691250 Review.
-
Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumours by activating the FGFR1-PI3K-Rac1 pathway.Br J Cancer. 2010 Jul 27;103(3):370-81. doi: 10.1038/sj.bjc.6605775. Epub 2010 Jul 6. Br J Cancer. 2010. PMID: 20606682 Free PMC article.
-
Synergistic induction of cancer cell migration regulated by Gβγ and phosphatidylinositol 3-kinase.Exp Mol Med. 2012 Aug 31;44(8):483-91. doi: 10.3858/emm.2012.44.8.055. Exp Mol Med. 2012. PMID: 22627809 Free PMC article.
-
CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell.BMC Cancer. 2019 May 27;19(1):499. doi: 10.1186/s12885-019-5671-8. BMC Cancer. 2019. PMID: 31133010 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Miscellaneous
