Review
doi: 10.1038/nrmicro1441.
Epub 2006 Jun 12.
The co-evolution of host cationic antimicrobial peptides and microbial resistance
Affiliations
- PMID: 16778838
- DOI: 10.1038/nrmicro1441
Item in Clipboard
Review
The co-evolution of host cationic antimicrobial peptides and microbial resistance
Nat Rev Microbiol.
2006 Jul.
Abstract
Endogenous cationic antimicrobial peptides (CAMPs) are among the most ancient and efficient components of host defence. It is somewhat of an enigma that bacteria have not developed highly effective CAMP-resistance mechanisms, such as those that inhibit many therapeutic antibiotics. Here, we propose that CAMPs and CAMP-resistance mechanisms have co-evolved, leading to a transient host-pathogen balance that has shaped the existing CAMP repertoire. Elucidating the underlying principles of this process could help in the development of more sustainable antibiotics.
Similar articles
-
Are cationic antimicrobial peptides also 'double-edged swords'?Expert Rev Anti Infect Ther. 2008 Aug;6(4):453-62. doi: 10.1586/14787210.6.4.453. Expert Rev Anti Infect Ther. 2008. PMID: 18662113 Review.
-
Bacterial resistance to cationic antimicrobial peptides.Crit Rev Microbiol. 2013 May;39(2):180-95. doi: 10.3109/1040841X.2012.699025. Epub 2012 Jul 16. Crit Rev Microbiol. 2013. PMID: 22799636 Review.
-
Cationic host defense (antimicrobial) peptides.Curr Opin Immunol. 2006 Feb;18(1):24-30. doi: 10.1016/j.coi.2005.11.004. Epub 2005 Dec 6. Curr Opin Immunol. 2006. PMID: 16337365 Review.
-
[Antimicrobial peptides: a new way to treat bacterial infections].Orv Hetil. 2001 Jan 28;142(4):169-71. Orv Hetil. 2001. PMID: 11232153 Review. Hungarian.
-
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?Nat Rev Microbiol. 2005 Mar;3(3):238-50. doi: 10.1038/nrmicro1098. Nat Rev Microbiol. 2005. PMID: 15703760 Review.
Cited by
-
Solid-phase synthesis of fusaricidin/LI-F class of cyclic lipopeptides: Guanidinylation of resin-bound peptidyl amines.Biopolymers. 2013 Apr;100(2):160-6. doi: 10.1002/bip.22186. Biopolymers. 2013. PMID: 23436339 Free PMC article.
-
Designing antimicrobial peptides: form follows function.Nat Rev Drug Discov. 2011 Dec 16;11(1):37-51. doi: 10.1038/nrd3591. Nat Rev Drug Discov. 2011. PMID: 22173434 Review.
-
Extracellular Polymeric Substance Protects Some Cells in an Escherichia coli Biofilm from the Biomechanical Consequences of Treatment with Magainin 2.Microorganisms. 2021 Apr 30;9(5):976. doi: 10.3390/microorganisms9050976. Microorganisms. 2021. PMID: 33946431 Free PMC article.
-
Cationic antimicrobial peptide LL-37 is effective against both extra- and intracellular Staphylococcus aureus.Antimicrob Agents Chemother. 2013 Mar;57(3):1283-90. doi: 10.1128/AAC.01650-12. Epub 2012 Dec 28. Antimicrob Agents Chemother. 2013. PMID: 23274662 Free PMC article.
-
Enhanced amphiphilic profile of a short β-stranded peptide improves its antimicrobial activity.PLoS One. 2015 Jan 24;10(1):e0116379. doi: 10.1371/journal.pone.0116379. eCollection 2015. PLoS One. 2015. PMID: 25617899 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous
