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Review
. 2007 Mar;126(1-3):16-24.
doi: 10.1016/j.bpc.2006.05.004. Epub 2006 May 13.

Microcalorimetry of biological macromolecules

Peter L Privalov  1 , Anatoly I Dragan
Affiliations
Review

Microcalorimetry of biological macromolecules

Peter L Privalov et al. Biophys Chem. 2007 Mar.

Abstract

The capabilities of contemporary differential scanning and isothermal titration microcalorimetry for studying the thermodynamics of protein unfolding/refolding and their association with partners, particularly target DNA duplexes, are considered. It is shown that the predenaturational changes of proteins must not be ignored in studying the thermodynamics of formation of their native structure and their complexes with partners, particularly their cognate DNA duplexes.

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