Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Jul;16(5):141-6.
doi: 10.1016/j.tcm.2006.03.001.

Cardioprotection by adiponectin

Noriyuki Ouchi  1 , Rei Shibata, Kenneth Walsh
Affiliations
Review

Cardioprotection by adiponectin

Noriyuki Ouchi et al. Trends Cardiovasc Med. 2006 Jul.

Abstract

Obesity-related disorders are closely associated with the pathogenesis of cardiovascular disease. Adiponectin is a circulating adipose tissue-derived hormone that is down-regulated in obese individuals. Hypoadiponectinemia has been identified as an independent risk factor for type 2 diabetes, coronary artery disease, and hypertension, and experimental studies show that adiponectin plays a protective role in the development of insulin resistance, atherosclerosis, and inflammation. More recent findings have shown that adiponectin directly affects signaling in myocardial cells and exerts beneficial actions on the heart after pressure overload and ischemia-reperfusion injury. This review focuses on the role of adiponectin in the regulation of myocardial remodeling and acute cardiac injury.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Cardioprotective actions of adiponectin. Plasma adiponectin level is negatively regulated by adiposity, which is influenced by the levels of food intake and physical activity. Adiponectin stimulates myocardial AMPK signaling, leading to a suppression of myocyte hypertrophy and apoptosis. Adiponectin also stimulates COX-2 expression, resulting in reduction in cardiac inflammation.
See this image and copyright information in PMC

References

    1. Al Suwaidi J, Higano ST, Holmes DR, et al. Obesity is independently associated with coronary endothelial dysfunction in patients with normal or mildly diseased coronary arteries. J Am Coll Cardiol. 2001;37:1523–1528. - PubMed
    1. Anker SD, Ponikowski P, Varney S, et al. Wasting as independent risk factor for mortality in chronic heart failure. Lancet. 1997;349:1050–1053. - PubMed
    1. Arita Y, Kihara S, Ouchi N, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun. 1999;257:79–83. - PubMed
    1. Arita Y, Kihara S, Ouchi N, et al. Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation. 2002;105:2893–2898. - PubMed
    1. Berg AH, Scherer PE. Adipose tissue, inflammation, and cardiovascular disease. Circ Res. 2005;96:939–949. - PubMed

Publication types