Comment
doi: 10.1016/j.cub.2006.05.032.
Cell biology: Ran, mitosis and the cancer connection
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- PMID: 16782004
- DOI: 10.1016/j.cub.2006.05.032
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Comment
Cell biology: Ran, mitosis and the cancer connection
Curr Biol.
.
Free article
Abstract
The small GTPase Ran has been shown to regulate HURP, a protein that interacts with several mitotic spindle assembly factors. This discovery sheds new light on the role of Ran in the fidelity of mitosis and in cancer.
Comment on
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HURP is a Ran-importin beta-regulated protein that stabilizes kinetochore microtubules in the vicinity of chromosomes.Curr Biol. 2006 Apr 18;16(8):731-42. doi: 10.1016/j.cub.2006.02.070. Curr Biol. 2006. PMID: 16631580
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HURP is part of a Ran-dependent complex involved in spindle formation.Curr Biol. 2006 Apr 18;16(8):743-54. doi: 10.1016/j.cub.2006.03.056. Curr Biol. 2006. PMID: 16631581
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