Review
doi: 10.1016/j.immuni.2006.06.007.
Outside influence: TLRs direct hematopoietic cell fates
Affiliations
- PMID: 16782021
- DOI: 10.1016/j.immuni.2006.06.007
Item in Clipboard
Review
Outside influence: TLRs direct hematopoietic cell fates
Immunity.
2006 Jun.
Free article
Abstract
Toll-like receptors (TLRs) modulate immune responses indirectly by promoting the efficacy of antigen presentation. In this issue of Immunity, Nagai et al. (2006) demonstrate that TLR signals also bias hematopoietic progenitor cells toward myelopoiesis directly by replacing cytokine and differentiative cues.
Comment on
-
Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment.Immunity. 2006 Jun;24(6):801-812. doi: 10.1016/j.immuni.2006.04.008. Immunity. 2006. PMID: 16782035 Free PMC article.
Similar articles
-
Direct Toll-like receptor-mediated stimulation of hematopoietic stem and progenitor cells occurs in vivo and promotes differentiation toward macrophages.Stem Cells. 2012 Jul;30(7):1486-95. doi: 10.1002/stem.1110. Stem Cells. 2012. PMID: 22511319
-
Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment.Immunity. 2006 Jun;24(6):801-812. doi: 10.1016/j.immuni.2006.04.008. Immunity. 2006. PMID: 16782035 Free PMC article.
-
Dectin-1 Stimulation of Hematopoietic Stem and Progenitor Cells Occurs In Vivo and Promotes Differentiation Toward Trained Macrophages via an Indirect Cell-Autonomous Mechanism.mBio. 2020 Jun 23;11(3):e00781-20. doi: 10.1128/mBio.00781-20. mBio. 2020. PMID: 32576672 Free PMC article.
-
Toll-like receptor signaling in hematopoietic stem and progenitor cells.Curr Opin Hematol. 2019 Jul;26(4):207-213. doi: 10.1097/MOH.0000000000000511. Curr Opin Hematol. 2019. PMID: 31033704 Review.
-
Contribution of Aberrant Toll Like Receptor Signaling to the Pathogenesis of Myelodysplastic Syndromes.Front Immunol. 2020 Jun 17;11:1236. doi: 10.3389/fimmu.2020.01236. eCollection 2020. Front Immunol. 2020. PMID: 32625214 Free PMC article. Review.
Cited by
-
The Role of Toll-like Receptor Agonists and Their Nanomedicines for Tumor Immunotherapy.Pharmaceutics. 2022 Jun 10;14(6):1228. doi: 10.3390/pharmaceutics14061228. Pharmaceutics. 2022. PMID: 35745800 Free PMC article. Review.
-
Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes.Int J Mol Sci. 2023 Feb 15;24(4):3896. doi: 10.3390/ijms24043896. Int J Mol Sci. 2023. PMID: 36835307 Free PMC article.
-
Regenerative stromal cell therapy in allogeneic hematopoietic stem cell transplantation: current impact and future directions.Biol Blood Marrow Transplant. 2010 Jul;16(7):891-906. doi: 10.1016/j.bbmt.2009.12.005. Epub 2009 Dec 16. Biol Blood Marrow Transplant. 2010. PMID: 20018250 Free PMC article. Review.
-
Unraveling the Pathogenesis of MDS: The NLRP3 Inflammasome and Pyroptosis Drive the MDS Phenotype.Front Oncol. 2016 Jun 16;6:151. doi: 10.3389/fonc.2016.00151. eCollection 2016. Front Oncol. 2016. PMID: 27379212 Free PMC article. Review.
-
Role of innate immunological/inflammatory pathways in myelodysplastic syndromes and AML: a narrative review.Exp Hematol Oncol. 2023 Jul 8;12(1):60. doi: 10.1186/s40164-023-00422-1. Exp Hematol Oncol. 2023. PMID: 37422676 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
