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. 1991 Sep;73(3):275-7.
doi: 10.1213/00000539-199109000-00008.

Resistance to vecuronium in patients with cerebral palsy

S S Moorthy  1 , G Krishna, S F Dierdorf
Affiliations

Resistance to vecuronium in patients with cerebral palsy

S S Moorthy et al. Anesth Analg. 1991 Sep.

Erratum in

  • Anesth Analg 1992 Jun;74(6):933-4

Abstract

To determine the electromyographic response of patients with cerebral palsy to vecuronium, 10 children (mean age, 6 yr 10 mo) without cerebral palsy and 11 children with cerebral palsy (mean age, 10 yr 3 mo) were studied. All patients were undergoing abdominal or orthopedic surgery and were anesthetized with isoflurane and nitrous oxide. The time from intravenous administration of 0.1 mg/kg of vecuronium to 25% recovery of control twitch height was 43.9 +/- 5.3 and 18.9 +/- 1.7 min (mean +/- SEM) in children without and with cerebral palsy, respectively (P less than 0.01). The authors conclude that patients with cerebral palsy are either resistant to vecuronium or have a rapid clearance as evidenced by the rapid recovery from neuromuscular blockade.

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