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. 2006 Jul;13(7):661-2.
doi: 10.1038/nsmb1114. Epub 2006 Jun 18.

Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme

Tao Wang  1 , Xiangbin Zhang, Poonam Bheda, Javier R Revollo, Shin-ichiro Imai, Cynthia Wolberger
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Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme

Tao Wang et al. Nat Struct Mol Biol. 2006 Jul.

Abstract

Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD+ biosynthetic pathway and is required for SirT1 activity in vivo. Nampt has also been presumed to be a cytokine (PBEF) or a hormone (visfatin). The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism.

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  • A close look at NAD biosynthesis.
    Mattevi A. Mattevi A. Nat Struct Mol Biol. 2006 Jul;13(7):563-4. doi: 10.1038/nsmb0706-563. Nat Struct Mol Biol. 2006. PMID: 16826227 No abstract available.

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