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. 2006 Aug;48(2):195-203.
doi: 10.1016/j.toxicon.2006.04.018. Epub 2006 May 22.

Isolation and identification of a cis-C8-diol-ester of okadaic acid from Dinophysis acuta in New Zealand

Christopher O Miles  1 , Alistair L Wilkins, Allan D Hawkes, Dwayne J Jensen, Janine M Cooney, Kristofer Larsen, Dirk Petersen, Frode Rise, Veronica Beuzenberg, A Lincoln Mackenzie
Affiliations

Isolation and identification of a cis-C8-diol-ester of okadaic acid from Dinophysis acuta in New Zealand

Christopher O Miles et al. Toxicon. 2006 Aug.

Abstract

A cis-isomer of a C(8)-diol ester of okadaic acid (1) was isolated during large-scale purification of pectenotoxins (PTXs) from extracts of Dinophysis acuta collected from the west coast of South Island, New Zealand. The compound was identified by NMR spectroscopic and liquid chromatography-mass spectrometry (LC-MS) studies, and is the first reported cis-isomer of an okadaic acid C(8)-diol-ester identified in Dinophysis. The more abundant trans-C(8)-diol ester of okadaic acid (2) isolated from the same Dinophysis extract was rapidly hydrolyzed to okadaic acid in vitro by the supernatant from green-lipped mussel hepatopancreas.

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