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. 2006 Sep 1;16(17):4609-11.
doi: 10.1016/j.bmcl.2006.06.008. Epub 2006 Jun 19.

Vasorelaxant activity of cyclic peptide, cyclosquamosin B, from Annona squamosa

Hiroshi Morita  1 , Toru Iizuka, Chee-Yan Choo, Kit-Lam Chan, Koichi Takeya, Jun'ichi Kobayashi
Affiliations

Vasorelaxant activity of cyclic peptide, cyclosquamosin B, from Annona squamosa

Hiroshi Morita et al. Bioorg Med Chem Lett. .

Abstract

A cyclic octapeptide, cyclosquamosin B (2), isolated from the seeds of Annona squamosa showed a vasorelaxant effect on rat aorta. It showed a slow relaxation activity against norepinephrine (NE)-induced contractions of rat aorta with/without endothelium. It showed inhibition effect on vasocontraction of depolarized aorta with high concentration potassium, but moderately inhibition effect on NE-induced contraction in the presence of nicardipine. These results showed that the vasorelaxant effect by 2 might be attributed mainly to inhibition of calcium influx from extracellular space through voltage-dependent calcium channels.

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