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Review
. 2006 Jul;37(7):781-6.
doi: 10.1016/j.humpath.2006.03.013.

B-RAF mutations in the etiopathogenesis, diagnosis, and prognosis of thyroid carcinomas

Vítor Trovisco  1 , Paula Soares, Manuel Sobrinho-Simões
Affiliations
Review

B-RAF mutations in the etiopathogenesis, diagnosis, and prognosis of thyroid carcinomas

Vítor Trovisco et al. Hum Pathol. 2006 Jul.

Abstract

The very recent discovery of B-RAF point mutations as the most prevalent genetic alteration in papillary thyroid carcinoma has revolutionized the molecular knowledge of thyroid malignancies. In this review, we address the role played by such mutations in the etiopathogenesis, diagnosis, prognosis, and therapy selection of thyroid cancer, with an emphasis on papillary carcinoma.

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