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. 2006 Jun;91(6 Suppl):ECR27.

Corticosteroids can reverse severe imatinib-induced hepatotoxicity

Dario Ferrero  1 , Enrico Maria Pogliani, Giovanna Rege-Cambrin, Carmen Fava, Giovanna Mattioli, Chiara Dellacasa, Elisabetta Campa, Paola Perfetti, Monica Fumagalli, Mario Boccadoro
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  • PMID: 16785130

Corticosteroids can reverse severe imatinib-induced hepatotoxicity

Dario Ferrero et al. Haematologica. 2006 Jun.

Abstract

Background: Imatinib can induce severe hepatotoxicity, in 1-5% of CML patients, many of whom need permanent imatinib discontinuation.

Design and results: We report 5 CML patients who developed grade 3-4 hepatotoxicity after 2-8 months in imatinib. Different aetiologies of liver damage were ruled out and toxicity recurred in 2 patients with further attempts at low dose imatinib. In all patients prednisone or methylprednisolone at 25- 40 mg/day resolved hepatotoxicity in 3-8 weeks and allowed imatinib to be resumed at full doses. Corticosteroid were tapered off in 3-5 months without hepatotoxicity recurrence.

Conclusions: Corticosteroid may avoid discontinuation for hepatotoxicity of the most effective anti-CML therapy.

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