Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2006 Jun 20;174(13):1843-4.
doi: 10.1503/cmaj.051446.

Pulmonary hypertension following L-lysine ibuprofen therapy in a preterm infant with patent ductus arteriosus

Carlo Bellini  1 , Francesco Campone, Giovanni Serra
Affiliations
Case Reports

Pulmonary hypertension following L-lysine ibuprofen therapy in a preterm infant with patent ductus arteriosus

Carlo Bellini et al. CMAJ. .

Abstract

Patent ductus arteriosus is one of the most common congenital abnormalities found in premature infants. Ibuprofen, a nonsteroidal drug that is commonly used as an antipyretic, analgesic and anti-inflammatory agent, is also used to induce closure of symptomatic patent ductus arteriosus in preterm infants. Recently, we gave L-lysine ibuprofen to a preterm infant with respiratory distress to induce closure of a patent ductus arteriosus, and the infant experienced pulmonary hypertension. Only 3 cases of pulmonary hypertension following early administration of an ibuprofen solution buffered with tromethamine have previously been reported. However, this severe side effect has never been observed in multicentre, randomized, double-blind controlled trials, nor in recent reviews or meta-analyses of L-lysine ibuprofen use.

PubMed Disclaimer

Figures

None
Fig. 1: Anteroposterior chest radiography taken 2 hours after birth.
See this image and copyright information in PMC

Comment in

References

    1. Wyllie J. Treatment of patent ductus arteriosus. Semin Neonatol 2003;8:425-32. - PubMed
    1. Thomas RL, Parker GC, Van Overmeire B, et al. A meta-analysis of ibuprofen versus indomethacin for closure of patent ductus arteriosus. Eur J Pediatr 2005;164:135-40. - PubMed
    1. Shah SS, Ohlsson A. Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants [Cochrane Review]. In: The Cochrane Library; Issue 2, 2005. Oxford: Update Software. - PubMed
    1. Gournay V, Roze JC, Kuster A, et al. Prophylactic ibuprofen versus placebo in very premature infants: a randomised, double-blind, placebo-controlled trial. Lancet 2004;364:1939-44. - PubMed
    1. Van Overmeire B, Allegaert K, Casaer A, et al.; Multicentre Ibuprofen Prophylaxis Study (MIPS) Investigators. Prophylactic ibuprofen in premature infants: a multicentre, randomised, double-blind, placebo-controlled trial. Lancet 2004;364:1945-9. - PubMed

Publication types

MeSH terms