Destabilizing heterochromatin: Does Swi6/HP1 make the choice?
- PMID: 16793539
- DOI: 10.1016/j.molcel.2006.06.004
Destabilizing heterochromatin: Does Swi6/HP1 make the choice?
Abstract
HP1 is well known as a key silencing protein. However, in the June 9 issue of Molecular Cell, report that Swi6/HP1 recruits an antisilencing protein, Epe1, to facilitate transcription, leading to a model in which Swi6/HP1 is used as a platform to recruit both silencing and antisilencing activities.
Comment on
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Swi6/HP1 recruits a JmjC domain protein to facilitate transcription of heterochromatic repeats.Mol Cell. 2006 Jun 9;22(5):681-92. doi: 10.1016/j.molcel.2006.05.010. Mol Cell. 2006. PMID: 16762840
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