Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Jun 24;332(7556):1506-8.
doi: 10.1136/bmj.332.7556.1506.

Is restricted randomisation necessary?

Affiliations
Review

Is restricted randomisation necessary?

Catherine E Hewitt et al. BMJ. .

Abstract

Restrictions during randomisation make it easier for investigators to guess the next allocation. Statistical correction of any imbalance in confounders at the end of the study is equally accurate for most trials and would be safer

PubMed Disclaimer

Figures

Figure 1
Figure 1
What will come next? Credit: PHOTOS.COM

References

    1. Altman DG, Bland JM. Statistics notes: How to randomise. BMJ 1999;319: 703-4. - PMC - PubMed
    1. Altman DG, Bland JM. Treatment allocation by minimisation. BMJ 2005;330: 843. - PMC - PubMed
    1. Schulz KF. Subverting randomisation in controlled trials. JAMA 1995;274: 1456-8. - PubMed
    1. Kennedy A, Grant A. Subversion of allocation in a randomised controlled trial. Control Clin Trials 1997;18: S77-8.
    1. Berger V. Selection bias and covariate imbalances in randomized clinical trials. Chichester: Wiley, 2005. - PubMed

Publication types

MeSH terms