Properties of acidic saccharides produced by B16 melanoma cells treated with 1-methyl-3-isobutylxanthine
- PMID: 167957
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Properties of acidic saccharides produced by B16 melanoma cells treated with 1-methyl-3-isobutylxanthine
Cancer Res.
1975 Sep.
Abstract
A cyclic nucleotide phosphodiesterase inhibitor, 1-methyl-3-isobutylxanthine, promoted the differentiation and maturation of B16 melanoma cells, phenomena associated with biological alterations in the surface properties of the cells. 1-Methyl-3-isobutylxanthien inhibited cell replication and increased the intracellular content of melanin and cyclic adenosine 3':5'-monophosphate. Significantly greater amounts of sialoglycoproteins were associated with 1-methyl-3-isobutylxanthine-treated cells. However, the total amount of [3H] glucosamine incorporated into anionic polysaccharide (both sialoglycopeptide and mucopolysaccharides) was not significantly changed.
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